Accomplishments

Coherence Tomography: Collaborative Research and Service

LAMMP collaborator Dr. Mark Linskey, Chair of Neurosurgery, with flexible OCT probe for neurovascular aneuryism imaging.

• The importance of dynamic visualization of changes in the structure of corneal incisions for cataract surgery was demonstrated. (P. McDonnel et al., 2003)
• Polarization-sensitive OCT was used as an approach for highly sensitive burn depth measurements in animal models. (S. Srinivas et al., 2003)
• Fundamental structural contrast elements of oral cancer including epithelial thickening and degradation of basement membrane were characterized in an animal model. (P. Wilder-Smith et al., 2004)
• The feasibility of minimally-invasive human laryngeal diagnostics was demonstrated in 82 patients with normal tissue architecture and benign pathology (B. Wong et al., 2005), and subsequently in laryngeal cancer patients. (W. Armstrong et al., 2006)
• Fundamental studies investigating the dispersion of laminar flow were performed in microchannels imaged dynamically and in 3-D using optical Doppler tomography. (Y-C. Ahn et al., 2005)

Dr. William Armstrong, Chair of Head and Neck Surgery, with OCT endoscope for laryngeal diagnostics.

• A compact office-based OCT system was developed and tested for vocal chord screening and diagnostics. (S. Guo et al., 2006)
• Polarization contrast in OCT was shown to provide new diagnostic information content for characterizing degenerative joint disease. (T. Xie et al, 2006)
• Enamel erosion and demineralization in teeth were shown to be quantifiable endpoints using functional OCT signals. (P. Wilder-Smith et al., 2007)