ATKs
Application Tool Kits (ATKs) will utilize both standard and sophisticated
methods and will be packaged using a graphical user interface to facilitate
use by researchers who may lack specialized training in Biophotonics. The
ATKs will: (a) enable powerful simulations in realistic tissue geometries
to guide the design of experiments and instrumentation; (b) provide new
insights into the fundamental information content of detected optical
signals; and (c) serve as an important educational tool for young researchers
in biomedical optics. The capabilities and design of the ATKs will be
developed and tested in concert with both internal LAMMP users and external
collaborators.
Figure 1: FOPATK: The objective of this toolkit
is to provide a platform to examine the effectiveness of a given fiber probe
configuration (e.g., fiber number, diameter, orientation, numerical aperture,
source-detector separation, etc.) to establish a desired dosimetry profile,
interrogate an internal tissue structure and/or provide data sufficient to
extract accurate optical properties of a heterogeneous tissue volume.
Interrogation Density Maps (IDMs) provide transport-rigorous, absolute measures
of the probability that different tissue regions with be both sampled and detected
by a particular probe configuration. These maps will enable the FOPATK user
to adjust their probe design to target selected regions within the tissue.
Figure 2: (a) IDM for breast system with the inclusion of
a tumor with 2x the absorption of the surrounding tissue, (b) relative difference
between the IDM for the tumor-containing and homogeneous system for a tumor
with 2x the absorption of the surrounding tissue, (c) relative difference between
the IDM for the tumor-containing and homogeneous system for a tumor with
20% increase in scattering and a 2x increase in absorption.
