VTS
The overall goal of this LAMMP core activity is to develop a modular and scalable computational platform, the Virtual Tissue Simulator (VTS), to provide an integrated suite of computational tools to define, solve, visualize, and analyze relevant forward and inverse radiative transport problems in biomedical optics. The VTS will allow tissue representations that consist of an assembly of ‘primitive’ tissue elements (e.g., cells, matrix, vasculature) specified by images provided by histology, CT or MRI. The tools within VTS will be designed to accommodate a variety of irradiation and detection schemes relevant to the optical interrogation of cells and tissues on microscopic, mesoscopic, and macroscopic spatial scales. The VTS will provide various capabilities not only to visualize and further analyze the solver output but also to address important inverse problems connected with the recovery of optical properties, optical image reconstruction, and measurement design.
Figure 1: (a) Histology of port wine stain identifying the the epidermis, dermis and vascular regions and calculated absorbed energy density (b) without the port wine stain and (c) with the port wine stain.
