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Quantitiative Optical Tomography of Sub-surface Heterogeneities using Spatially Modulated Structured Light

Abstract
We present a wide-field method for obtaining three-dimensional images of turbid media. By projecting patterns of light of varying spatial frequencies on a sample, we reconstruct quantitative, depth resolved images of absorption contrast. Images are reconstructed using a fast analytic inversion formula and a novel correction to the diffusion approximation for increased accuracy near boundaries. The method provides more accurate quantification of optical absorption and higher resolution than standard diffuse reflectance measurements.

Quantitiative Optical Tomography of Sub-surface Heterogeneities using Spatially Modulated Structured Light Opt. Express, 17(17), 14780-90, 2009 NIHMS 180116

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