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Developing compact multiphoton systems using femtosecond fiber lasers

We implement a fiber-delivered compact femtosecond fiber laser at 1030-nm wavelength in multiphoton imaging. The laser pulse duration is 150 fs, the average power is 200 mW, and the repetition rate is 40 MHz. The laser measures 200 x 160 x 45 mm in size and its output is delivered through a photonic bandgap fiber. Intrinsic second-harmonic generation signal is excited from rat tail tendon and human skin samples. Twophoton excited fluorescence signal is obtained from human skin tissues stained with exogenous fluorophore. Our results show that femtosecond fiber lasers at 1030-nm wavelength have significant potential in developing compact, all-fiber-based, portable multiphoton systems and endoscopes.

Developing compact multiphoton systems using femtosecond fiber lasers Shuo Tang,1 Jian Liu,2 Tatiana B. Krasieva,3 Zhongping Chen,3 and Bruce J. Tromberg3 1University of British Columbia, Department of Electrical and Computer Engineering, 2332 Main Mall, Vancouver, British Columbia, V6T 1Z4 Canada 2PolarOnyx, Inc., 470 Lakeside Drive, Suite F, Sunnyvale, California 94085 3University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92617 J. Biomedical Opt., 14(3), 030508, 2009, NIHMS 165508

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