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Optical Coherence Tomography (OCT)

OCT is a non-invasive, non-contact imaging modality based on coherence gating where the short coherence length of a broadband light source is used in an interferometer to obtain micrometer-scale, cross-sectional imaging of biological tissue. The high spatial resolution of the OCT structural image enables noninvasive in vivo "optical biopsy" and provides immediate and localized tissue structure information. Functional OCT (FOCT) is an extension of OCT for functional imaging of tissue physiology to enhance the diagnostic capability of OCT. All F-OCT has Doppler and Phase resolved Doppler OCT capability. F-OCT fiber-based platforms are available for collaborative projects that image blood vessels, retina, airway, oral cavity, GI tract, skin, cartilage as well as other tissues. There are currently 4 F-OCT instruments available for collaborative studies.

Features commmon to all:
  • Depth resolution: 5-10 µm
  • Lateral resolution: 10 µm
  • Imaging speed: 1- 50 frames/second
  • Sensitivity: 95-108 dB
  • Varying probes for endoscopic clinic imaging: rotational and linear scanning
  • Center wavelength: 1310 nm
  • Functional capability: Structure, blood flow velocity (Doppler) and birefringence (polarization) imaging
Specific features:

TDOCT

  • Rapid scanning optical delay line
  • Cart-based system for transport
  • Generally used for clinical and animal studies (can be shipped offsite)
  • Currently housed in LAMMP

SDOCT

  • Spectrometer system
  • Capable of 3D imaging
  • Imaging at up to 7 frames/second
  • Sensitivity of 105 dB
  • Currently housed in LAMMP

SSOCT

  • Swept laser system
  • Imaging at up to 16 frames/second
  • Sensitivity of 108 dB
  • Generally used for clinical and animal studies
  • Currently housed in LAMMP

SSOCT II

  • Swept laser system
  • Imaging at up to 50 frames/second
  • Sensitivity of 106 dB
  • Generally used for clinical and animal studies
  • Currently housed in LAMMP

FDOCT-MC

  • Swept laser system
  • Imaging at up to 50 frames/second
  • Sensitivity of 106 dB
  • Linear scanning endoscopic probe for use in clinical studies
  • Generally used for clinical studies
  • Currently housed at UCI Medical Center
  • Custom designed endoscopic probes upon request

[Return to list of shared instrumentation]

Research

Contact Us

  • Hanna Kim
    Resource Coordinator
    Phone:949.824.2251
    Email: hhkim3@uci.edu

Supported by


P41EB015890