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From Optical Spectroscopy to Spectroscopic Imaging

Quan Liu

My research has been focused in the field of biomedical optics. My group not only explores novel optical technology but also develops biomedical devices based on those relatively mature optical technologies and investigates the applications of such devices in targeted disease management and biological science research. In particular, I will talk about our contributions in the following topics related to optical spectroscopy and spectroscopic imaging.
1. Development of experimental and numerical methods for depth sensitive optical spectroscopy
Epithelial tissue is layered but most optical probes average signals from a large tissue volume. This limits the accuracy of optical diagnosis in epithelial cancers and precancers. In response to this challenge, we published one of the first papers in depth sensitive fluorescence spectroscopy using an angled fiber-optic probe design. To overcome the limitation of the fiber-optic probe in optical coupling uncertainty, we have proposed multiple lens based systems to perform depth sensitive optical spectroscopy. Moreover, relevant numerical tools based on the Monte Carlo method were also developed to facilitate the optimization of such systems.

2. Development of fast spectroscopic imaging for biomedical applications.
While the power of Raman spectroscopy and imaging has been recognized in biomedical fields, slow Raman acquisition has become a critical issue that prevents Raman techniques from being widely adopted. We have been investigating a unique approach to address this issue, which is narrow-band imaging for the quick collection of required data followed by spectral reconstruction to recover high spectral resolution. This approach has the advantages of snapshot imaging and rapid post data processing to speed up spectroscopic Raman imaging. We have developed a series of relevant methods to implement this approach. Results from both phantoms and cells will be shown.

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