Laser Microbeam and Medical Program    »     People  |   Education & Dissemination  |   Research & Resources  |   Publications
LASER MICROBEAM AND MEDICAL PROGRAM (LAMMP) SEMINARS

Rare-earth doped nanocomposites for targeted short-wave infrared imaging of cancer

Mark C. Pierce, PhD

Rare-earth (RE) doped nanocomposites with near-infrared excitation and short-wave infrared (SWIR) emissions benefit from reduced optical scattering and low tissue autofluorescence to provide deeper imaging capability than visible or near infrared probes. Encapsulating RE nanoparticles within an albumin shell and functionalizing with AMD3100 promotes targeting to CXCR4, a recognized biomarker for highly metastatic breast cancer. This presentation will describe RE nanocomposite spectroscopy, synthesis and biofunctionalization, alongside development of macroscopic (whole-animal) and microscopic (sub-cellular) SWIR imaging systems. Results will be reported from an ongoing study using these technologies to detect and track early micrometastatic lesions in breast cancer.

[ Back ]

sponsored by

The Laser Microbeam and Medical Program (LAMMP)
a NIH biotechnology resource facility at the Beckman Laser Institute

LAMMP Seminars

View selected seminars online

Education & Dissemination

Contact Us

  • Hanna Kim
    Resource Coordinator
    Phone:949.824.2251
    Email: hhkim3@uci.edu

Supported by


P41EB015890