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LASER MICROBEAM AND MEDICAL PROGRAM (LAMMP) SEMINARS

Imaging Amphotericin B’s Mechanism of Action with Transient Absorption Microscopy

Tessa R. Calhoun, PhD


The dramatic rise of antimicrobial resistance in current drug treatments necessitates new strategies to combat life threatening infections. Key insight into this problem may be found in the antifungal amphotericin B (AmB) as the clinical use of this drug for more than 50 years has been met with minimal occurrences of resistance. Despite decades of use and study, however, the mechanism governing this molecule’s efficacy is still highly debated. Our use of both nonlinear microscopic and spectroscopic tools provides new insight into the aggregation of this drug, which has been linked to its toxicity, and allows the first ever visualization of native AmB interacting with living yeast cells. In this talk, I will present our findings which suggest behavior of the drug not consistent with any previously proposed mechanisms of action.

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The Laser Microbeam and Medical Program (LAMMP)
a NIH biotechnology resource facility at the Beckman Laser Institute

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