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In vivo and ex vivo Imaging for Early Detection of Periodontal and Peri-Arthritic Bone Loss in an HLA/DR1 Mouse Model

Anastasios Karydis, DDS, MS, PhD


Rheumatoid Arthritis (RA) and periodontitis are common chronic inflammatory diseases with multifactorial etiology. RA is an autoimmune disorder that involves joint swelling and pain, and leads to chronic morbidity, while periodontitis has bacterial etiology, affects the periodontium (specialized joint), and leads to bone destruction and tooth loss. Inoculation of C57BL/6 mice expressing human HLA-DRĪ²1 (shared epitope associated with RA) with the periodontal pathogen Porphyromonas gingivalis results in periodontitis, while the wild type C57BL/6 mice are resistant. Using in vivo (IVIS) and ex vivo (high-resolution 3D microCT) imaging, we identify anatomic regions with early bone loss in the oral cavity, legs and paws. In addition, P gingivalis exposure triggered expression of arthritis in mice previously resistant to the development of clinical autoimmune arthritis, by tipping the immune response balance towards an overt arthritic phenotype.

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