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LAMMP Seminar Video
Photogeneration of singlet oxygen and free radicals by new bacteriochlorin and fullerene photosenitizers for photodynamic therapy of cancer and other diseases
Tadeusz J. Sarna, M.D., Ph.D., D.Sc.

Photodynamic therapy (PDT) is a novel modality for treatment of tumors and some other diseases with light, photosensitizing dyes and molecular oxygen. PDT is based on photoactivation of photosensitzer molecules, which, via the interaction with molecular oxygen and substrate molecules, generate singlet oxygen and free radicals. These reactive oxygen species (ROS) exert toxic effects on cells of the pathological tissue and its blood supply system leading to selective cell death and removal of the pathological lesion. The type of the photosensitizer photochemistry, responsible for generation of singlet oxygen and free radicals, depends on physiochemical properties of the photosensitizing dye molecules and their microenvironment.This lecture will discuss mechanistic aspects of PDT based on photophysical and photochemical studies of a recently synthesized Pd-substituted bacteriocholin derivative and functionalized C60 fullerenes.

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