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LAMMP Seminar Video
Tumor microvasculature and microenvironment: Novel insight using intravital microscopy.
Dai Fukumura, MD, PhD

Intravital microscopy has provided unprecedented insights in tumor pathophysiology including angiogenesis and the microenvironment. Tumor vasculature has abnormal organization, structure, and function causing hostile metabolic microenvironment characterized by hypoxia and acidosis. It also results in ineffective delivery of therapeutic agents in tumors and unsuccessful outcome of anti-tumor treatments such as radiation therapy and chemotherapy. In addition, host-tumor interactions regulate expression of pro- and anti-angiogenic factors. Imbalance of these factors results in above-mentioned pathophysiological features in the tumor. In a physiological setting, angiogenic vessels eventually become mature and stable vessels that represent long-lasting functional units. Restoring the balance of pro- and anti-angiogenic factors in tumors may “normalize” tumor vasculature, improve its function and thus, efficacy of concomitantly administered cytotoxic therapies.

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