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LAMMP Seminar Video
Towards Prediciting PDT response of head and neck lesions at the OR
Ulas Sunar, PhD

Photodynamic therapy (PDT) has recently shown potential for treating head and neck cancer. For improved PDT efficacy, there is a need for quantitative tools that can monitor PDT. In this talk, I will present statistical results from a Phase I clinical trial of 2-1[hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH)-mediated PDT in head and neck cancer patients. We used a custom probe that combined diffuse correlation spectroscopy (DCS), diffuse reflectance spectroscopy (DRS) and diffuse fluorescence spectroscopy (DFS) for quantification of blood flow, blood volume, blood oxygenation and HPPH fluorescence. Non-invasive measurements were acquired before and after treatment. Our results from 20 patients point out differences in these parameters between the lesion and periphery at pre-treatment. We also observed significant inter- and intra-lesion heterogeneity before and after PDT. PDT-induced changes in these parameters correlated with STAT3 crosslinking, a molecular marker of accumulated PDT dose. Our results suggest diffuse optical spectroscopies can provide quantitative markers that show PDT response in early stage.

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