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LAMMP Seminar Video
Intraoperative guidance with intrinsic near infrared imaging
Anita Mahadevan-Jansen, PhD

For endocrine diseases where surgery is the only curative option, the success of procedures depends on complete resection of benign and malignant parathyroid or thyroid tissue during the time of surgery. Complications arise because the surgeon relies on visual inspection and professional experience during surgery to identify the parathyroid glands, which are small and variable in location. Inadvertent injury to or removal of the parathyroid during such procedures is the leading reason for litigation amongst endocrine surgeons. We have developed near infrared autofluroescence spectroscopy for the intraoperative identification of the parathyroid gland. Our current goal is to provide real time feedback to the surgeon by translating this technology into the imaging domain. The basis for the fluorescence detected in the parathyroid is a novel, unidentified NIR biological fluorophore that is excited at 785 nm with peak emission at 822 nm and the presence of which has previously remained unreported. In a more recent development in our laboratory, we have observed similar fluorescence in normal skeletal muscle that surround soft tissue sarcomas and this has formed the basis for another project where we combine near infrared autofluorescence with Raman spectroscopy for the intraoperative assessment of margins in soft tissue sarcomas. Results this far from both these projects will be presented with the goal towards potential clinical translation.

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