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LAMMP Seminar Video
Advances and Applications in Label-free Cell-based Assays
Jeff Irelan, PhD

Label-free approaches to phenotypic screening allow for real-time dynamic monitoring of cellular responses. Cell morphology, attachment, proliferation and migration phenotypes can be altered in response to modulators of many disease-relevant pathways. For many targets, direct measurement of these characteristics allows for evaluation of endogenously expressed targets and pathways in a therapeutically relevant cellular context, and is thus a perfect fit for phenotypic approaches to discovery research. We have developed novel assays for receptor activation and for dynamic monitoring of cardiomyocyte beating. Additionally, we will discuss the application of label free assays at several stages in the development of our novel oncology therapeutics.

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